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Particle size reduction pharmaceutics

particle size reduction pharmaceutics

In the next few sections, our focus will center on the effect of magnesium stearate on the manufacturing process and product performance.
Regarding lubrication, lubricity indexa measure of over-lubrication-can be expressed as: (cunlubricated clubricated cunlubricated, where cunlubricate and clubricated are un-lubricated and lubricated crush strengths for compacts; the formulation containing the dihydrate showed the least tendency to cause over-lubrication.
In the following discussion, we will focus our attention on the effect of magnesium stearate on process and product performance, including the effect of its pseudo-polymorphic properties on lubrication, the impact of powder properties on blend flowability, and the influence of lubrication on compaction/compression dynamics.To further verify, powder X-ray diffraction was used 3 suisses reduction internet to examine the mixture of stearic acid and povidone, showing that stearic acid lost its crystallinity.It appeared that grinding accelerated the solid-state interaction of captopril with magnesium stearate.API active pharmaceutical ingredient, aSD amorphous solid dispersion, aUC area under the curve.In terms of the process of adding a lubricant, the lubricant is often added at the end of the granulation process in the outer phase when other components safari niagara promo code 2015 have been mixed thoroughly.The optimal concentration of commonly used lubricants for preparing solid dosage forms.
In terms of the method of lubrication, it was found that mixing the lubricant with MCC powders (bulk-lubrication) was much more effective than just spraying the lubricant to press surfaces (roll-lubrication).
However, there are other lubricants, including fatty acid esters, inorganic materials, and polymers, which can be used in the cases when both magnesium stearate and stearic acid do not meet their performance expectation.
The incompatibility of magnesium stearate with a drug also depends on the functional groups of the drug.As reported, the lubrication efficiency of magnesium stearate as a lubricant varies from one hydration state to another; in general, the dihydrate is considered to be the most efficient lubricant of all, due to its crystal structure which is suitable for shearing.As a result, the flowability, permeability, porosity, and compressibility of a particular formulation lubricated with magnesium stearate depend on its moisture content or the RH of storage conditions.Other drugs, found to be incompatible with magnesium stearate, include glimepiride, cephalexin, glipizide, ibuproxam, indomethacin, ketoprofen, moexipril, nalidixic acid, primaquine, promethazine hydrochloride, temazepam, glibenclamide, penicillin G, oxacillin, clopidogrel besylate and erythromycin.However, the NIR method with partial least squares regression analysis is more sensitive to the presence of small quantities of hydrates.Furthermore, the distribution of magnesium stearate among substrate particles and its film formation around the substrate particles is also dependent on the mixing speed and the equipment used as shown by the study.Finally, in addition to its pseudo-polymorphic effect on lubrication, the powder properties or the solid properties of magnesium stearate such as particle size, particle morphology, and surface area also influence the lubrication performance of formulations with magnesium stearate, and this will be discussed in the.

Friction and Adhesion, in general, friction is almost always associated with adhesion.
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In terms of boundary lubrication, the addition of a lubricant in formulations is to reduce the coefficient of wall friction by forming a boundary layer.